Denali Therapeutics Inc., a biopharmaceutical company, discovers and develops therapeutic candidates for neurodegenerative diseases in the United States. It offers leucine-rich repeat kinase 2 (LRRK2) inhibitor product candidate, including BIIB122/DNL151, a small molecule inhibitor, which is in phase I and phase Ib clinical trials for the treatment of Parkinson's disease. The company also develops DNL310 that is in Phase I/II clinical trials for the treatment of hunter syndrome; DNL343, which is in phase 1 clinical trial the treatment of amyotrophic lateral sclerosis (ALS); AR443820/DNL788 completed a phase I clinical trial for the treatment of ALS, multiple sclerosis (MS), and Alzheimer's disease; and SAR443122/DNL758, which is in phase II clinical trial for the treatment of cutaneous lupus erythematosus. It has collaboration agreement with Takeda Pharmaceutical Company, Genentech, Inc., Sanofi, F-star Gamma Limited, F-star Biotechnologische Forschungs-Und Entwicklungsges M.B.H, F-star Biotechnology Limited, SIRION Biotech GmbH, Genzyme Corporation, Harvard University, the Michael J. Fox Foundation, and Centogene; and a research and option agreement with Secarna Pharmaceuticals GmbH & Co. KG. to develop antisense therapies in the field of neurodegenerative diseases. The company was formerly known as SPR Pharma Inc. and changed its name to Denali Therapeutics Inc. in March 2015. Denali Therapeutics Inc. was incorporated in 2013 and is headquartered in South San Francisco, California.

Schuth Alexander O.

Watts Ryan J.

BAKER BROS. ADVISORS LP

Ho Carole

Privium Fund Management acquired 254,857 shares of Denali Therapeutics for approximately $5.07 million in Q1 2026, representing a new 1.02% position in their portfolio. The investment comes after the FDA granted accelerated approval for Denali's first commercial drug, Avlayah, which treats Hunter syndrome and validates their TransportVehicle platform for crossing the blood-brain barrier. While the approval is significant, Denali remains a high-risk biotech bet with $966 million in cash but a $512 million loss in 2025.

Privium Fund Opens $5.07 Million Denali Stake Ahead of FDA Drug Approval

Professional Trader, 10+ years experience - Founder at https://t.co/oHBJyNQTZd and https://t.co/GEJpgVvdaY.

Denali Therapeutics Inc (DNLI) Stock Price, Analysis & Trade Signals